Science Library Category:

Neurodevelopmental Injury

Published: 2018
SYNOPSIS

The preponderance of the evidence indicates that Hg exposure is causal and/or contributory to ASD.

TITLE

Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting

CITATION

Maria Elisabeth Street, et al. International Journal of Molecular Sciences, 2018, 19, 1647.

SUMMARY

This manuscript reviews the reports of a multidisciplinary national meeting on the effects of endocrine-disrupting chemicals (EDCs). Section 3 specifically discusses EDCs and neurodevelopmental diseases in humans, with a focus on autism. Recent studies point to an equal contribution of environmental factors, particularly environmental toxicants, and genetic susceptibility, but only a few industrial chemicals (e.g., lead (Pb), methylmercury, polychlorinated biphenyls (PCBs), arsenic (As), and toluene) are recognized causes of neurodevelopmental disorders and subclinical brain dysfunction. The recent discovery that heavy metals such as cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni), and lead (Pb) may exhibit endocrine-disrupting activity in animal models, probably by interfering with zinc-fingers of nuclear estrogen receptors. The authors review research on mercury, PCBs, Polycyclic Aromatic Hydrocarbons, Polybrominated Diphenyl Ethers, Phthalates, BPAs, and pesticides.

View Abstract

TAGS

, , ,

Published: 2016
SYNOPSIS

There is a significant increase in neurodevelopmental delays in children exposed to both Thimerosal (in vaccines) and methylmercury (in fish).

TITLE

Neurodevelopment of Amazonian children exposed to ethylmercury (from Thimerosal in vaccines) and methylmercury (from fish)

CITATION

Rejane C. Marques, Luciana Abreu, José V.E. Bernardi, José G. Dórea. Environmental Research, 149 (2016), 259–265.

SUMMARY

Amazonian children exposed to high and low levels of both ethyl and methylmercury were assessed using the Mental Developmental Index and Psychomotor Developmental Index. Statistically significant differences were seen in the high exposure group at 24 months in the mental developmental index only. Combined exposures led to developmental delays including the age of talking and the age of walking.

View Abstract

TAGS
Published: 2016
SYNOPSIS

Mercury exposure is implicated in neuroinflammatory disorders including autism.

TITLE

The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder

CITATION

Gehan Ahmed Mostafa, Geir Bjørklund, Mauricio A. Urbina, Laila Yousef AL-Ayadhi. Metabolic Brain Disease, June 2016, Volume 31, Issue 3, pp 593–599.

SUMMARY

Blood mercury levels and tachykinins (neuropeptides that cause inflammation) were correlated in children with ASD and statistically significantly higher than neurotypical control children. It has been shown that mercury exposure can elicit tachykinin formation which has been implicated in neuroinflammatory disorders including autism.

View Abstract

TAGS

,

Published: 2015
SYNOPSIS

Thimerosal exposure in humans many neurodevelopment deficits even at levels currently administered in vaccines.

TITLE

Thimerosal: Clinical, epidemiologic and biochemical studies

CITATION

David A. Geier, Paul G. King, Brian S. Hooker, José G. Dórea, Janet K. Kern,
Lisa K. Sykes, Mark R. Geier.Clinica Chimica Acta, 444 (2015) 212–220 February 2015.

SUMMARY

This review article includes a section on numerous papers linking thimerosal exposure via infant vaccines to autism. The publication also includes a critique of studies supported or conducted by the U.S. Centers for Disease Control (CDC) that deny any associations between exposure to thimerosal in vaccines and the subsequent development of autism. The CDC has been criticized by Congress for inherent conflicts of interest related to its vaccine development activities and role in vaccine safety oversight.

View Abstract

TAGS

Published: 2014
SYNOPSIS

Neurodevelopmental disorders are much more common in children who received mercury-containing vaccines.

TITLE

A Dose-Response Relationship between Organic Mercury Exposure from Thimerosal-Containing Vaccines and Neurodevelopmental Disorders

CITATION

David A. Geier, Brian S. Hooker, Janet K. Kern, Paul G. King, Lisa K. Sykes, and Mark R. Geier, International Journal of Environmental Research and Public Health 2014, 11, 9156-9170; doi:10.3390/ijerph110909156

SUMMARY

On a per microgram of organic-mercury (Hg) basis, Pervasive Developmental Disorder, specific developmental disorder, tic disorder and hyperkinetic syndrome of childhood cases were significantly more likely than controls to receive increased organic-Hg exposure. This study provides new epidemiological evidence supporting a significant relationship between increasing organic-Hg exposure from vaccines and the subsequent risk of an Neurodevelopmental Disorder diagnosis.

View Abstract

TAGS

, , , ,

Published: 2013
SYNOPSIS

This article highlights the connection between infant and prenatal thimerosal exposure and neurological disorders.

TITLE

Low-Dose Mercury Exposure in Early Life: Relevance of Thimerosal to Fetuses, Newborns and Infants

CITATION

José G. Dórea. Current Medicinal Chemistry, 2013, 20, 4060-4069.

SUMMARY

This review article highlights the scientifically affirmed connection between infant and prenatal thimerosal exposure and neurological disorders, including tic disorder, which has been shown to be much more prevalent in children with autism. The author also delineates the use of thimerosal in vaccines in developing countries at a greater exposure level than developed countries such as the U.S.

View Abstract

TAGS

,

Published: 2005
SYNOPSIS

Many heavy metals increase the apparent toxicity of low levels of mercury.

TITLE

Mercury toxicity: Genetic susceptibility and synergistic effects

CITATION

B.E. Haley. Medical Veritas, 2 (2005) 535–542.

SUMMARY

This article discusses mercury intoxication and several normally appearing factors that increase the susceptibility to mercury toxicity. Boys with autism represent a subset of the population that is more susceptible to the toxic effects of mercury and thimerosal because they are not efficient excretors of these toxic materials. Research confirms that a lead toxic person would be more susceptible to mercury toxicity than a healthy, non-toxic person researchers routinely observed that many heavy metals increase the apparent toxicity of low levels of mercury. In other words, the synergistic effects of other heavy metals, diet, antibiotics, etc. on mercury toxicity make it impossible to define a “safe level of mercury exposure.”

View Abstract

TAGS

, ,