Science Library Category:

Neurodevelopmental Injury

Published: 2018
SYNOPSIS

The preponderance of the evidence indicates that Hg exposure is causal and/or contributory to ASD.

TITLE

Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting

CITATION

Maria Elisabeth Street, et al. International Journal of Molecular Sciences, 2018, 19, 1647.

SUMMARY

This manuscript reviews the reports of a multidisciplinary national meeting on the effects of endocrine-disrupting chemicals (EDCs). Section 3 specifically discusses EDCs and neurodevelopmental diseases in humans, with a focus on autism. Recent studies point to an equal contribution of environmental factors, particularly environmental toxicants, and genetic susceptibility, but only a few industrial chemicals (e.g., lead (Pb), methylmercury, polychlorinated biphenyls (PCBs), arsenic (As), and toluene) are recognized causes of neurodevelopmental disorders and subclinical brain dysfunction. The recent discovery that heavy metals such as cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni), and lead (Pb) may exhibit endocrine-disrupting activity in animal models, probably by interfering with zinc-fingers of nuclear estrogen receptors. The authors review research on mercury, PCBs, Polycyclic Aromatic Hydrocarbons, Polybrominated Diphenyl Ethers, Phthalates, BPAs, and pesticides.

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Published: 2018
SYNOPSIS

Fluoride and aluminum, alone or in combination, can produce the condition of “immunoexcitotoxicity” that leads to the pathological changes seen in autism. 

TITLE

Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: a possible role of fluoride and aluminum

Citation

Strunecka A, Blaylock RL, Patocka J, Strunecky O. Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: a possible role of fluoride and aluminum. Surgical Neurology International. 2018;9:74.

 

Summary

Children experience sequential immune stimulation from a growing number of neurotoxic metals and chemicals, vaccines and persistent viral infections. This excessive immune activation is the “initiating and sustaining event” in autism spectrum disorder (ASD), triggering inflammation and a cascade of excitotoxicity (damaged nerve cells). The fluoride added to drinking water and the aluminum in vaccines—singly or synergistically as aluminofluoride—can be potent factors in producing the condition of “immunoexcitotoxicity” that leads to the pathological changes seen in ASD.

 

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Published: 2018
SYNOPSIS

The offspring of mothers exposed to DDT and its metabolites during pregnancy are at increased risk for autism.

TITLE

Association of maternal insecticide levels with autism in offspring from a national birth cohort

Citation

Brown AS, Cheslack-Postava K, Rantakokko P, et al. Association of maternal insecticide levels with autism in offspring from a national birth cohort. American Journal of Psychiatry. 2018;175(11):1094-1101.

 

Summary

The study provides the first evidence based on biomarkers of an increased autism risk in the offspring of mothers exposed to certain insecticides during pregnancy. In this large national birth cohort study of Finnish children, the odds of autism plus intellectual disability were increased by greater than twofold in mothers measuring with the highest levels of a DDT metabolite.

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Published: 2018
SYNOPSIS

In children under age two, four postnatal risk factors (acetaminophen use, antibiotic use, ear infections and early weaning) were associated with an increased risk of autism.

TITLE

Acetaminophen, antibiotics, ear infection, breastfeeding, vitamin D drops, and autism: an epidemiological study

Citation

Bittker SS, Bell KR. Acetaminophen, antibiotics, ear infection, breastfeeding, vitamin D drops, and autism: an epidemiological study. Neuropsychiatric Disease and Treatment. 2018;14:1399-1414.

 

Summary

This study suggests that increased use of acetaminophen and antibiotics in children under age two, along with an increased incidence of ear infections in the first two years and early weaning, are associated with an increased risk of autism spectrum disorder (ASD). The researchers conducted a large parent Internet survey covering over 1,500 three- to twelve-year-old children who either had or did not have ASD. The findings replicate other studies focused on these postnatal ASD risk factors.

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Published: 2018
SYNOPSIS

Two prenatal exposures—stress and maternal immune dysregulation—are associated with autism, probably in combination with other genetic and environmental risk factors.

TITLE

Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders

Citation

Beversdorf DQ, Stevens HE, Jones KL. Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders. Current Psychiatry Reports. 2018;20:76.

 

Summary

Prenatal stress and disruption of a pregnant woman’s immune response (“maternal immune activation”) are two environmental factors that have associated with the increased incidence of autism spectrum disorder (ASD). However, the fact that, in many cases, these prenatal exposures do not result in ASD suggests an “interaction with multiple other risks.” Some evidence points to greater susceptibility to prenatal stress and maternal immune dysregulation in male offspring.

Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders

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Published: 2016
SYNOPSIS

There is a significant increase in neurodevelopmental delays in children exposed to both Thimerosal (in vaccines) and methylmercury (in fish).

TITLE

Neurodevelopment of Amazonian children exposed to ethylmercury (from Thimerosal in vaccines) and methylmercury (from fish)

CITATION

Rejane C. Marques, Luciana Abreu, José V.E. Bernardi, José G. Dórea. Environmental Research, 149 (2016), 259–265.

SUMMARY

Amazonian children exposed to high and low levels of both ethyl and methylmercury were assessed using the Mental Developmental Index and Psychomotor Developmental Index. Statistically significant differences were seen in the high exposure group at 24 months in the mental developmental index only. Combined exposures led to developmental delays including the age of talking and the age of walking.

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Published: 2016
SYNOPSIS

Mercury exposure is implicated in neuroinflammatory disorders including autism.

TITLE

The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder

CITATION

Gehan Ahmed Mostafa, Geir Bjørklund, Mauricio A. Urbina, Laila Yousef AL-Ayadhi. Metabolic Brain Disease, June 2016, Volume 31, Issue 3, pp 593–599.

SUMMARY

Blood mercury levels and tachykinins (neuropeptides that cause inflammation) were correlated in children with ASD and statistically significantly higher than neurotypical control children. It has been shown that mercury exposure can elicit tachykinin formation which has been implicated in neuroinflammatory disorders including autism.

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Published: 2015
SYNOPSIS

Thimerosal exposure in humans many neurodevelopment deficits even at levels currently administered in vaccines.

TITLE

Thimerosal: Clinical, epidemiologic and biochemical studies

CITATION

David A. Geier, Paul G. King, Brian S. Hooker, José G. Dórea, Janet K. Kern,
Lisa K. Sykes, Mark R. Geier.Clinica Chimica Acta, 444 (2015) 212–220 February 2015.

SUMMARY

This review article includes a section on numerous papers linking thimerosal exposure via infant vaccines to autism. The publication also includes a critique of studies supported or conducted by the U.S. Centers for Disease Control (CDC) that deny any associations between exposure to thimerosal in vaccines and the subsequent development of autism. The CDC has been criticized by Congress for inherent conflicts of interest related to its vaccine development activities and role in vaccine safety oversight.

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Published: 2014
SYNOPSIS

Neurodevelopmental disorders are much more common in children who received mercury-containing vaccines.

TITLE

A Dose-Response Relationship between Organic Mercury Exposure from Thimerosal-Containing Vaccines and Neurodevelopmental Disorders

CITATION

David A. Geier, Brian S. Hooker, Janet K. Kern, Paul G. King, Lisa K. Sykes, and Mark R. Geier, International Journal of Environmental Research and Public Health 2014, 11, 9156-9170; doi:10.3390/ijerph110909156

SUMMARY

On a per microgram of organic-mercury (Hg) basis, Pervasive Developmental Disorder, specific developmental disorder, tic disorder and hyperkinetic syndrome of childhood cases were significantly more likely than controls to receive increased organic-Hg exposure. This study provides new epidemiological evidence supporting a significant relationship between increasing organic-Hg exposure from vaccines and the subsequent risk of an Neurodevelopmental Disorder diagnosis.

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Published: 2013
SYNOPSIS

This article highlights the connection between infant and prenatal thimerosal exposure and neurological disorders.

TITLE

Low-Dose Mercury Exposure in Early Life: Relevance of Thimerosal to Fetuses, Newborns and Infants

CITATION

José G. Dórea. Current Medicinal Chemistry, 2013, 20, 4060-4069.

SUMMARY

This review article highlights the scientifically affirmed connection between infant and prenatal thimerosal exposure and neurological disorders, including tic disorder, which has been shown to be much more prevalent in children with autism. The author also delineates the use of thimerosal in vaccines in developing countries at a greater exposure level than developed countries such as the U.S.

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Published: 2005
SYNOPSIS

Many heavy metals increase the apparent toxicity of low levels of mercury.

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Mercury toxicity: Genetic susceptibility and synergistic effects

CITATION

B.E. Haley. Medical Veritas, 2 (2005) 535–542.

SUMMARY

This article discusses mercury intoxication and several normally appearing factors that increase the susceptibility to mercury toxicity. Boys with autism represent a subset of the population that is more susceptible to the toxic effects of mercury and thimerosal because they are not efficient excretors of these toxic materials. Research confirms that a lead toxic person would be more susceptible to mercury toxicity than a healthy, non-toxic person researchers routinely observed that many heavy metals increase the apparent toxicity of low levels of mercury. In other words, the synergistic effects of other heavy metals, diet, antibiotics, etc. on mercury toxicity make it impossible to define a “safe level of mercury exposure.”

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