Science Library Category:

Maternal Immune Activation

Published: 2018
SYNOPSIS

Two prenatal exposures—stress and maternal immune dysregulation—are associated with autism, probably in combination with other genetic and environmental risk factors.

TITLE

Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders

Citation

Beversdorf DQ, Stevens HE, Jones KL. Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders. Current Psychiatry Reports. 2018;20:76.

 

Summary

Prenatal stress and disruption of a pregnant woman’s immune response (“maternal immune activation”) are two environmental factors that have associated with the increased incidence of autism spectrum disorder (ASD). However, the fact that, in many cases, these prenatal exposures do not result in ASD suggests an “interaction with multiple other risks.” Some evidence points to greater susceptibility to prenatal stress and maternal immune dysregulation in male offspring.

Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders

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