Science Library Category:

Infertility

Published: 2014
SYNOPSIS

FDA’s instruction to health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility” lacks science and compromises safety monitoring by undermining “reporting efficiency” safety signaling and informed consent.

TITLE

Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination: A Case Series Seen in General Practice.

CITATION

Little DT, Ward HR. Journal of Investigative Medicine- High Impact Case Reports, 2014 Oct 28; 2(4):2324709614556129.

SUMMARY

Published case reports have considered a possible link between quadrivalent human papillomavirus vaccine and premature ovarian failure. Declining menstrual function in girls aged 14, 15, and 20 years followed HPV4 vaccination and preceded premature ovarian failure. Long-term follow-up data after HPV vaccination has not surveyed ovarian function, recorded, measured, or analyzed symptoms or signs of dysfunction. Disparagement of adverse event reporting by licensing bodies’ instruction to health providers that “there is no biologically plausible way in which HPV vaccine could cause infertility” lacks science and compromises safety monitoring by undermining “reporting efficiency” safety signaling and informed consent. Public reassurance that “studies have not found ovarian failure to be associated with HPV vaccination” in the absence of sound research may be harmful to vaccine confidence.

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