Science Library Category:

Gastrointestinal Symptoms

Published: 2019
SYNOPSIS

With the preliminary literature search starting in 2013 and looking backwards in time, research publications revealed a myriad of toxic actions of Aluminum causing pathological conditions.

TITLE

Aluminium toxicosis: a review of toxic actions and effects

CITATION

Ikechukwu Onyebuchi Igbokwe, Ephraim Igwenagu, Nanacha Afifi Igbokwe. Interdiscip Toxicol. 2019; Vol. 12(2): 45–70. doi: 10.2478/intox-2019-0007

SUMMARY

Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn’s disease, inflammatory bowel diseases, anemia, Alzheimer’s disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance.

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Published: 2018
SYNOPSIS

Autistic children with gastrointestinal symptoms have an imbalance in their immune response that affects behavior and quality of life.

TITLE

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

CITATION

Rose DR, Yang H, Serena G, Sturgeon C, Ma B, Careaga M, Hughes HK, Angkustsiri K, Rose M, Hertz-Picciotto I, Van de Water J, Hansen RL, Ravel J, Fasano A, Ashwood P. Brain, Behavior, and Immunity. 2018;70:354-368.

SUMMARY

Children with autism spectrum disorder (ASD) and concurrent gastrointestinal (GI) symptoms have a more imbalanced immune response, a more disturbed gut microbiome and worse behavioral outcomes (such as irritability, agitation, social withdrawal, lethargy, hyperactivity and noncompliance) than ASD children without GI symptoms. The study additionally looked at typically developing children with and without GI symptoms and found that ASD+GI children stood out compared to those two groups as well. Children with ASD plus GI symptoms may have a “propensity” toward leaky gut that contributes to their other symptoms and clinical outcomes.

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Published: 2013
SYNOPSIS

Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects

CITATION

Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.

SUMMARY

Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.

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