Science Library Category:

Gastrointestinal Symptoms

Published: 2018
SYNOPSIS

Autistic children with gastrointestinal symptoms have an imbalance in their immune response that affects behavior and quality of life.

TITLE

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

CITATION

Rose DR, Yang H, Serena G, Sturgeon C, Ma B, Careaga M, Hughes HK, Angkustsiri K, Rose M, Hertz-Picciotto I, Van de Water J, Hansen RL, Ravel J, Fasano A, Ashwood P. Brain, Behavior, and Immunity. 2018;70:354-368.

SUMMARY

Children with autism spectrum disorder (ASD) and concurrent gastrointestinal (GI) symptoms have a more imbalanced immune response, a more disturbed gut microbiome and worse behavioral outcomes (such as irritability, agitation, social withdrawal, lethargy, hyperactivity and noncompliance) than ASD children without GI symptoms. The study additionally looked at typically developing children with and without GI symptoms and found that ASD+GI children stood out compared to those two groups as well. Children with ASD plus GI symptoms may have a “propensity” toward leaky gut that contributes to their other symptoms and clinical outcomes.

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Published: 2013
SYNOPSIS

Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects

CITATION

Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.

SUMMARY

Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.

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