Close menu
Science Library Category:

Diabetes

Published: 2023
SYNOPSIS

During the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 vaccination-induced hyperglycemia and related complications have been reported. However, there have been few reports of type 1 diabetes triggered by COVID-19 vaccines in subjects without diabetes.

TITLE

Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination

H. Moon, S. Suh, M. Kyoung Park

During the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 vaccination-induced hyperglycemia and related complications have been reported. However, there have been few reports of type 1 diabetes triggered by COVID-19 vaccines in subjects without diabetes. Here, we report the case of a 56-year-old female patient who developed hyperglycemia after the second dose of COVID-19 mRNA-based vaccination without a prior history of diabetes. She visited our hospital with uncontrolled hyperglycemia despite administration of oral hyperglycemic agents. Her initial glycated hemoglobin level was high (11.0%), and fasting serum C-peptide level was normal. The fasting serum C-peptide level decreased to 0.269 ng/mL 5 days after admission, and the anti-glutamic acid decarboxylase antibody was positive. The patient was discharged in stable condition with insulin treatment. To our knowledge, this is the first case of the development of type 1 diabetes without diabetic ketoacidosis after mRNA-based COVID-19 vaccination, and is the oldest case of type 1 diabetes development under such circumstances.

View Abstract

View Abstract

TAGS

, ,

Published: 2023
SYNOPSIS

Ten days after receiving a COVID-19 vaccination, a 36-year-old female patient visited the hospital with diabetic ketoacidosis and was diagnosed with type 1 diabetes.

TITLE

Type 1 diabetes mellitus following COVID-19 RNA-based vaccine

K. Sakurai, D. Narita, N. Saito, T. Ueno, R. Sato, S. Niitsuma, K. Takahashi, Z. Arihara

The epidemic of coronavirus disease-2019 (COVID-19) is the major public health issue in the world. COVID-19 vaccines are one of the most effective strategies against COVID-19. Here we report a 36-year-old female patient who had thirst, polydipsia, polyuria, palpitations, loss of appetite, and fatigue 3 days after the first dose of COVID-19 RNA-based vaccines without a prior history of diabetes. Ten days after vaccination, she visited our hospital with diabetic ketoacidosis and was diagnosed with type 1 diabetes. Hyperglycemia (501 mg/dL), anion gap metabolic acidosis and ketonuria were observed. The glycated hemoglobin level was 7.0%. Islet-related autoantibodies were all negative. The glucagon tolerance test revealed attenuated secretion of insulin. Human leukocyte antigen was haplotype DRB1*0405-DQB1*0401, which was associated with type 1 diabetes in Japan. The present case suggests that COVID-19 RNA-based vaccines might trigger the onset of type 1 diabetes, even in subjects without prior histories of diabetes.

View Abstract

View Abstract

TAGS

, ,

Published: 2020
SYNOPSIS

From 2002 to 2012, type 1 and type 2 diabetes incidence increased 1.4% and 7.1%, respectively, among U.S. youths, highlighting the need for continued surveillance for diabetes among youths to monitor overall and group-specific trends, identify factors driving these trends, and inform health care planning.

TITLE

Trends in Incidence of Type 1 and Type 2 Diabetes Among Youths — Selected Counties and Indian Reservations, United States, 2002–2015

CITATION

Divers J, Mayer-Davis EJ, Lawrence JM, et al. Trends in Incidence of Type 1 and Type 2 Diabetes Among Youths — Selected Counties and Indian Reservations, United States, 2002–2015. MMWR Morb Mortal Wkly Rep 2020;69:161–165. DOI: http://dx.doi.org/10.15585/mmwr.mm6906a3

SUMMARY

From 2002 to 2015, the annual incidence of both type 1 and type 2 diabetes increased at constant rates among persons aged <20 years in selected counties and Indian reservations in the United States. Rates of increase in incidence were higher for type 2 diabetes (4.8% per year) than for type 1 (1.9%). Since 2012, the rate of increase in type 2 diabetes has not changed, and has also remained constant for type 1 diabetes, except among Asians and Pacific Islanders. These findings provide indicators of the number of new cases of type 1 and type 2 diabetes among U.S. youths and identify groups with increased incidences of both type 1 and type 2 diabetes. Diabetes is a chronic disease that requires lifelong treatment and manage-ment. Better understanding of the number of new cases of diabetes among youths helps in planning for health care needs and resources.

View Abstract

TAGS
Published: 2018
SYNOPSIS

Food proteins in vaccines can sensitize the immune system and trigger development of food allergies and other chronic conditions such as autism and type 1 diabetes.

TITLE

Milk containing vaccines cause milk allergies, EoE, autism and type 1 diabetes

CITATION

Arumugham V. BMJ. 2018;361:k2396. [Letter in response to Schulze MB et al., Food based dietary patterns and chronic disease prevention, BMJ 2018;361:k2396.]

SUMMARY

Responding to an article about food and chronic illness, the author criticizes the researchers for overlooking “a major cause of why food has become dangerous,” noting that vaccines contain food proteins that can “program the immune system to recognize food as pathogens.” Injection of vaccines containing cow’s milk proteins can cause sensitization to several bovine proteins (casein, folate receptor and insulin). In addition, studies suggest an association between vaccine-induced sensitization to cow’s milk proteins and the development of eosinophilic esophagitis (EoE), autism and type 1 diabetes.

 

View Abstract

TAGS
Published: 2018
SYNOPSIS

The contamination of vaccines with animal proteins that resemble human proteins can trigger autoimmunity.

TITLE

Cancer immunology, bioinformatics and chemokine evidence link vaccines contaminated with animal proteins to autoimmune disease: a detailed look at Crohn’s disease and Vitiligo

Citation

Arumugham V, Trushin MV.  Journal of Pharmaceutical Sciences and Research. 2018;10(8):2106-2110.

Summary

Vaccines are contaminated with animal proteins that resemble human proteins, and this can result in autoimmunity. This study, which used bioinformatics to analyze animal proteins in vaccines and their similarity to human proteins, adds to growing evidence of vaccines inducing autoimmune diseases such as type 1 diabetes, Crohn’s disease, vitiligo, systemic lupus erythematosus and rheumatoid arthritis. The authors suggest that the live viruses and aluminum adjuvants in certain vaccines can stimulate the activation of particular T cells that, upon activation, may cause autoimmune disease. Because autoimmune reactions vary from person to person, “not everyone will develop overt disease”; thus, autoimmune illness may represent the tip of a broader “iceberg” of subclinical effects.

View Abstract

TAGS
Published: 1997
SYNOPSIS

Addition of the Hepatitis B Vaccine in 1988 Increased the Rate of Type 1 Diabetes 1.62X in Children in New Zealand. The incidence of type I diabetes in person 0-19 years old living in Christchurch rose from 11.2 cases per 100,000 children annually in the years before the immunization program, 1982-1987, to 18.1 cases per 100,000 children annually ( P = .0008) in the years following the immunization, 1989-1991.

TITLE

The timing of pediatric immunizations and the risk of Insulin-Dependent diabetes mellitus

CITATION

Classen David C.; Classen, John Barthelow; Infectious Diseases in Clinical Practice: September-October 1997 – Volume 6 – Issue 7 – ppg 449-454.

SUMMARY

Insulin-dependent diabetes mellitus (IDDM) is believed to be an autoimmune disease induced by a variety of environmental stimuli. Vaccines and infectious agents have been suggested to have an influence, but most of this research has been centered on the ability of these agents to infect the pancreatic islet cells or contain antigens that mimic autoantigens. Classen found that administration of the diphtheria-tetanus-pertussis (DTP) and anthrax vaccines to mice and rats at birth prevented the development of diabetes, whereas administration of the DTP vaccine starting at 8 weeks was associated with an increased incidence of diabetes.

View Abstract

TAGS

,