Science Library Category:

Autoimmunity

Published: 2017
SYNOPSIS

Authors review cases of autoimmune reactions following vaccinations to determine underlying cause.

TITLE

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

CITATION

Vadalà M, Poddighe D, Laurino C, Palmieri B. European Association for Predictive Preventive & Personalized Medicine Journal, 2017 Jul 20;8(3):295-311.

SUMMARY

In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals.

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Published: 2016
SYNOPSIS

Israeli, Canadian, and Colombian scientists show that Gardasil vaccine triggers brain inflammation and autoimmunity in mice.

TITLE

Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil

CITATION

Rotem Inbar, Ronen Weiss, Lucija Tomljenovic, Maria-Teresa Arango, Yael Deri, Christopher A Shaw, Joab Chapman, Miri Blank, Yehuda Shoenfeld. Immunol Res, July 2016.

SUMMARY

“Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals…It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes…In light of these findings, this study highlights the necessity of proceeding with caution with respect to further mass-immunization practices with a vaccine of yet unproven long-term clinical benefit in cervical cancer prevention”

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Published: 2015
SYNOPSIS

Authors review current evidence about how vaccine adjuvants may trigger autoimmunity.

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On vaccine’s adjuvants and autoimmunity: Current evidence and future perspectives

CITATION

Pellegrino P, Clementi E, Radice S. Autoimmunity Reviews, 2015 Oct; 14(10):880-8.

SUMMARY

In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals.

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Published: 2015
SYNOPSIS

A review of the literature shows evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients.

TITLE

Vaccines, adjuvants and autoimmunity

CITATION

Guimarães LE, Baker B, Perricone C, Shoenfeld Y. Pharmacol Research, 2015 Oct; 100:190-209.

SUMMARY

In this review of the literature, there is evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome).

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Published: 2015
SYNOPSIS

Authors define individuals at risk of developing autoimmune/inflammatory syndrome induced by adjuvants–ASIA syndrome.

TITLE

Predicting post-vaccination autoimmunity: who might be at risk?

CITATION

Soriano A, Nesher G, Shoenfeld Y. Pharmacological Research, 2015 Feb; 92:18-22. doi: 10.1016/j.phrs.2014.08.002. Epub 2014 Sep 30.

SUMMARY

It has been postulated that autoimmunity could be triggered or enhanced by the vaccine immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA is uncommon. Yet, by defining individuals at risk we may further limit the number of individuals developing post-vaccination ASIA.

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Published: 2015
SYNOPSIS

Vaccines implicated in epidemic of food allergies.

TITLE

Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy

CITATION

Vinu Arumugham. (2015) Journal of Developing Drugs 4: 137. doi:10.4172/2329-6631.10001372015.

SUMMARY

“Numerous studies have demonstrated that food proteins contained in vaccines/injections induce food allergy. The IOM’s authoritative report has concluded the same. Allergen quantities in vaccines are unregulated. Today kids are more atopic. C-section births bias the newborn’s immune system towards IgE synthesis due to sub-optimal gut microbiome [19]. C-section birth rates have gone up 50% in the last few decades. The vaccine schedule has increased the number of vaccine shots to 30-40 and up to five vaccines are simultaneously administered to children. Vaccines also contain adjuvants such as aluminum compounds and pertussis toxin that bias towards IgE synthesis. Given these conditions, the predictable and observed outcome is a food allergy epidemic.”

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Published: 2013
SYNOPSIS

Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects

CITATION

Carlo Perricone, Serena Colafrancesco, Roei D. Mazor, Alessandra Soriano, Yehuda Shoenfeld. Journal of Autoimmunity, October 2013.

SUMMARY

“The data herein illustrate the critical role of environmental factors in the induction of autoimmunity. Indeed, it is the interplay of genetic susceptibility and environment that is the major player for the initiation of breach of tolerance. Several neurologic demyelinating diseases have been reported following vaccination, the main being Guillaine Barre syndrome (GBS). Another demyelinating disease associated with vaccines is the acute disseminated encephalomyelitis (ADEM). This is an inflammatory disease of the central nervous system frequently occurring post-vaccination. Rabies, diphtheria tetanus polio, smallpox, measles, mumps, rubella, Japanese B encephalitis, pertussis, influ-enza, hepatitis B, and the Hog vaccines have been called to be involved.”

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Published: 2013
SYNOPSIS

Canadian researchers: aluminum in vaccines can cause both autoimmunity and neurological damage.

TITLE

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

CITATION

Chris Shaw, L. Tomljenovic. Immunologic Research, (2013) 56:304–316 DOI 10.1007/s12026-013-8403-1.

SUMMARY

“In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome. Aluminum is added to vaccines to help the vaccine work more effectively, but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure. Thus, the problem with vaccine-derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. It is not really a matter of much debate that aluminum in various forms can be neurotoxic.”

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Published: 2013
SYNOPSIS

Scientists from Mexico and Israel explain adjuvants (aluminum) used in vaccines can induce autoimmunity.

TITLE

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

CITATION

Olga Vera-Lastra, Gabriela Medina, Maria Del-Pilar Cruz Dominguez, Luis J Jara. Expert Reviews-Clinical Immunology, 9(4), 361-373, 2013.

SUMMARY

“The activation of the immune system by adjuvants, a desirable effect, could trigger manifestations of autoimmunity or autoimmune disease. Recently, a new syndrome was introduced, autoimmune/inflammatory syndrome induced by adjuvants (ASIA), that includes postvaccination phenomena, macrophagic myofasciitis, Gulf War syndrome and siliconosis. Various adjuvants used in vaccines enhance a specific immune response against antigens and may produce autoimmunity and AID both in experimental models and humans. The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”

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Published: 2012
SYNOPSIS

Canadian researchers review literature on autoimmunity and neurological risks from vaccine adjuvant aluminum, express doubts regarding safety testing.

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Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

CITATION

L Tomljenovic, CA Shaw. Lupus, (2012) 21, 223–230.

SUMMARY

“Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In spite of the widespread agreement that vaccines are largely safe and serious adverse complications are extremely rare, a close scrutiny of the scientific literature does not support this view. For example, to date, the clinical trials that could adequately address vaccine safety issues have not been con- ducted (i.e., comparing health outcomes in vaccinated versus non-vaccinated children). Infants and young children should not be viewed as ”small adults.” Their unique physiology makes them much more vulnerable to noxious environ- mental insults in comparison with the adult population. In spite of this, children are routinely exposed to much higher levels of Al vaccine adjuvants than adults, even though adequate safety data on these compounds are lacking. That Al vaccine adjuvants can induce significant autoimmune conditions in humans can hardly be disputed, although still debatable is how common such side effects are. However, the existing data (or lack thereof) raise questions on whether the current vaccines aimed at pediatric populations can be accepted as having adequate safety profiles. Because infants and children represent those who may be most at risk for complications following vaccination, a more rigorous evaluation of potential vaccine-related adverse health impacts in pediatric populations than what has been provided to date is urgently needed.”

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Published: 2010
SYNOPSIS

It is feasible that vaccinations may also contribute to the mosaic of autoimmunity.

TITLE

Vaccines and autoimmune diseases of the adult.

CITATION

Orbach H, Agmon-Levin N, Zandman-Goddard G. Discovery Medicine, 2014 May; 10(2):101-7.

SUMMARY

Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the development of these diseases is presented in this review.

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Published: 2009
SYNOPSIS

Swedish researchers found that children who had natural measles infection had much lower rates of allergy than children vaccinated against measles.

TITLE

Allergic Disease and Atopic Sensitization in Children in Relation to Measles Vaccination and Measles Infection

CITATION

Rosenlund H1, Bergstrom A, Alm JS, Swartz J, Scheynius A, van Hage M, Johansen K, Brunekreef B, von Mutius E, Ege MJ, Riedler J, Braun-Fahrlander C, Waser M, Pershagen G, PARSIFAL Study Group. Pediatrics, 2009.

SUMMARY

“However, in these analyses, measles infection [natural measles] was inversely associated with any allergic symptom or physician’s diagnosis of allergy.”

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