Science Library Category:

Autoimmunity

Published: 2019
SYNOPSIS

Residual animal, plant, fungal, aeroallergen proteins (non-target proteins in general) in vaccines cause numerous disorders  including rheumatoid arthritis. The solution is to immediately remove all non-target antigens from vaccines using technologies such as affinity chromatography. 

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Autoepitopes (22 of 27) in rheumatoid arthritis differ from vaccine antigens by a single amino acid residue, ideal for low affinity self-reactive T cell mediated autoimmunity and a…

CITATION

Arumugham, Vinu. 2019, September.

SUMMARY

Vaccines are manufactured using animal, plant, fungal derived growth media or recombinant organisms. They contain residual quantities of all these proteins. Vaccine makers do not want to spend the money to completely remove these residual proteins. Due to molecular mimicry between these proteins and human self-proteins, immune responses directed against vaccine proteins can result in autoimmune diseases.

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Published: 2018
SYNOPSIS

Severe, long-term disability and even death can occur in a subset of individuals vulnerable to “HPV vaccination syndrome.”

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Autoimmunity, autonomic neuropathy, and the HPV vaccination: a vulnerable subpopulation

Citation

Schofield JR, Hendrickson JE. Clinical Pediatrics. 2018;57(5):603-606.

Summary

The authors describe the first biopsy-proven case of serious nerve damage developing within days of HPV vaccination, with an evident link between symptom onset and vaccination. The authors advocate for “increased [provider] awareness of the potential for neurological complications” resulting from HPV vaccination, particularly due to the “devastating clinical outcome of severe, long-term disability and even death of [a vulnerable subset] affected by the HPV vaccination syndrome.”

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Published: 2017
SYNOPSIS

Adolescents given meningococcal vaccines have experienced a wide variety of serious adverse events, including new autoimmune conditions and death.

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Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine

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Hansen J, Zhang L, Klein NP, et al. Vaccine 2017;35(49 Pt B):6879-84.

 

SUMMARY

Adolescents receiving the Menactra® meningococcal vaccine (MenACWY-D) in 2005-2006 experienced a variety of adverse events in the six months following vaccination—including death—but the researchers (one of whom was affilated with the vaccine’s manufacturer, Sanofi Pasteur) concluded that only two diagnoses (diabetes and juvenile rheumatoid arthritis) were “possibly related to vaccination.” After comparing 31,000 Kaiser Permanente patients who received the MenACWY-D vaccine to 31,000 matched teens who had received a tetanus-diphtheria (Td) or hepatitis vaccine the previous year, the researchers assessed 1660 outcomes and determined that 1.3% were “significantly elevated” in the meningococcal group. There were two deaths in vaccinees with cancer (“with onset preceding vaccination”) following MenACWY-D vaccination as well as a third cardiac-related death; there was also one fetal death in a young woman who received Menactra® during pregnancy. Many of the adverse events, including difficulty breathing, occurred two or more months following vaccination.

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Published: 2017
SYNOPSIS

A number of factors can predispose susceptible individuals to autoimmune reactions following vaccination.

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Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

CITATION

Vadalà M, Poddighe D, Laurino C, Palmieri B. European Association for Predictive Preventive & Personalized Medicine Journal. 2017;8(3):295-311.

SUMMARY

This review discusses possible underlying mechanisms of autoimmune reactions following vaccinations and cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be those with previous post-vaccination phenomena, those with allergies, individuals who are prone to develop autoimmune diseases (such as those with a family history of autoimmunity or with known autoantibodies) and genetically predisposed individuals.

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Published: 2016
SYNOPSIS

Israeli, Canadian and Colombian scientists show that the Gardasil vaccine triggers brain inflammation and autoimmunity in mice.

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Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil

CITATION

Inbar R, Weiss R, Tomljenovic L, Arango M-T, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. Immunologic Research. 2017;65(1):136-149.

SUMMARY

“Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals…. It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes…. In light of these findings, this study highlights the necessity of proceeding with caution with respect to further mass-immunization practices with a vaccine of yet unproven long-term clinical benefit in cervical cancer prevention.”

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Published: 2015
SYNOPSIS

The specific mechanism of action of each vaccine adjuvant may have different effects on the course of autoimmune conditions resulting from vaccination.

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On vaccine’s adjuvants and autoimmunity: Current evidence and future perspectives

CITATION

Pellegrino P, Clementi E, Radice S. Autoimmunity Reviews. 2015;14(10):880-888.

SUMMARY

Adjuvants in vaccines have been implicated in “Autoimmune/inflammatory Syndrome Induced by Adjuvants” (ASIA), an umbrella of clinical conditions that includes post-vaccination adverse reactions. Aluminum-based compounds, in particular, are associated with the development of vaccine adjuvant-induced autoimmune diseases, but vaccines with other adjuvants may also cause specific autoimmune adverse reactions via different pathogenic mechanisms. The specific mechanism of action of each single adjuvant may have different effects on the course of different diseases.

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Published: 2015
SYNOPSIS

Evidence points to vaccine-induced autoimmunity and adjuvant-induced autoimmunity in experimental models and human patients.

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Vaccines, adjuvants and autoimmunity

CITATION

Guimarães LE, Baker B, Perricone C, Shoenfeld Y. Pharmacological Research. 2015;100:190-209.

SUMMARY

This review of the literature assembles evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

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Published: 2015
SYNOPSIS

Some individuals are at risk of developing autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

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Predicting post-vaccination autoimmunity: who might be at risk?

CITATION

Soriano A, Nesher G, Shoenfeld Y. Pharmacological Research, 2015;92:18-22. Epub 2014 Sep 30.

SUMMARY

It has been postulated that autoimmunity could be triggered or enhanced by a vaccine’s immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA (autoimmune/inflammatory syndrome induced by adjuvants) is uncommon. Yet, by defining individuals at risk, it may be possible to further limit the number of individuals developing post-vaccination ASIA.

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Published: 2015
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Vaccines are implicated in the epidemic of childhood food allergies.

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Evidence that food proteins in vaccines cause the development of food allergies and its implications for vaccine policy

CITATION

Arumugham V. Journal of Developing Drugs. 2015;4:137.

SUMMARY

Studies, including by the Institute of Medicine, have demonstrated that food proteins contained in vaccines/injections can induce food allergy. Allergen quantities in vaccines are unregulated. C-section births bias a newborn’s immune system toward IgE synthesis due to the development of a suboptimal gut microbiome. Vaccines contain adjuvants such as aluminum compounds and pertussis toxin that also bias toward IgE synthesis. Over several decades, C-section birth rates have gone up 50%, and the vaccine schedule has increased the number of vaccine shots, with up to five vaccines administered simultaneously. “Given these conditions, the predictable and observed outcome is a food allergy epidemic.”

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Published: 2013
SYNOPSIS

Israeli and Italian researchers demonstrate that exposure to aluminum in vaccines can lead to autoimmune and brain dysfunction.

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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects

CITATION

Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Journal of Autoimmunity. 2013;47:1-16.

SUMMARY

Environmental factors play a critical role in the induction of autoimmunity, with an interplay between genetic susceptibility and environment. Several neurologic demyelinating diseases have been reported following vaccination, notably Guillain-Barre syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) (an inflammatory disease of the central nervous system). A number of the most common vaccines appear to have some involvement with autoimmunity.

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Published: 2013
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Canadian researchers: aluminum in vaccines can cause both autoimmunity and neurological damage.

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Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

CITATION

Shaw C, Tomljenovic L. Immunologic Research. 2013;56:304–316.

SUMMARY

“In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome. Aluminum is added to vaccines to help the vaccine work more effectively, but unlike dietary aluminum which will usually clear rapidly from the body, aluminum used in vaccines and injected is designed to provide a long-lasting cellular exposure. Thus, the problem with vaccine-derived aluminum is really twofold: It drives the immune response even in the absence of a viral or bacterial threat and it can make its way into the central nervous system. It is not really a matter of much debate that aluminum in various forms can be neurotoxic.”

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Published: 2013
SYNOPSIS

Scientists from Mexico and Israel explain adjuvants (aluminum) used in vaccines can induce autoimmunity.

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Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

CITATION

Vera-Lastra O, Medina G, Del-Pilar Cruz Dominguez M, Jara LJ. Expert Reviews-Clinical Immunology. 2013;9(4):361-373.

SUMMARY

Activation of the immune system by adjuvants could trigger manifestations of autoimmunity or autoimmune disease. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) includes postvaccination phenomena, macrophagic myofasciitis (MMF), Gulf War syndrome and siliconosis. Various adjuvants used in vaccines enhance a specific immune response against antigens and may produce autoimmunity and autoimmune disease in experimental models and humans. “The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”

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Published: 2012
SYNOPSIS

Canadian researchers review literature on autoimmunity and neurological risks from vaccine adjuvant aluminum, express doubts regarding safety testing.

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Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

CITATION

L Tomljenovic, CA Shaw. Lupus. 2012;21:223–230.

SUMMARY

“Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In spite of the widespread agreement that vaccines are largely safe and serious adverse complications are extremely rare, a close scrutiny of the scientific literature does not support this view. For example, to date, the clinical trials that could adequately address vaccine safety issues have not been conducted (i.e., comparing health outcomes in vaccinated versus non-vaccinated children). Infants and young children should not be viewed as ‘small adults.’ Their unique physiology makes them much more vulnerable to noxious environmental insults in comparison with the adult population. In spite of this, children are routinely exposed to much higher levels of Al vaccine adjuvants than adults, even though adequate safety data on these compounds are lacking. That Al vaccine adjuvants can induce significant autoimmune conditions in humans can hardly be disputed, although still debatable is how common such side effects are. However, the existing data (or lack thereof) raise questions on whether the current vaccines aimed at pediatric populations can be accepted as having adequate safety profiles. Because infants and children represent those who may be most at risk for complications following vaccination, a more rigorous evaluation of potential vaccine-related adverse health impacts in pediatric populations than what has been provided to date is urgently needed.”

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Published: 2010
SYNOPSIS

It is feasible that vaccinations may contribute to the mosaic of autoimmunity.

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Vaccines and autoimmune diseases of the adult

CITATION

Orbach H, Agmon-Levin N, Zandman-Goddard G. Discovery Medicine. 2014;10(2):101-107.

SUMMARY

Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the development of these diseases is presented in this review.

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Published: 2009
SYNOPSIS

Swedish researchers found that children who had natural measles infection had much lower rates of allergy than children vaccinated against measles.

TITLE

Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection

CITATION

Rosenlund H, Bergstrom A, Alm JS, … PARSIFAL Study Group. Pediatrics. 2009;123(3):771-778.

SUMMARY

In these analyses, measles infection [natural measles] was inversely associated with any allergic symptom or physician’s diagnosis of allergy, suggesting that natural measles infection may protect against allergies in children.

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