Science Library Category:

Asthma

Published: 2019
SYNOPSIS

Children of mothers with asthma are at increased risk of developing autism, highlighting the importance of studying environmental risk factors during pregnancy.

TITLE

Parental asthma and risk of autism spectrum disorder in offspring: a population and family-based case-control study

Citation

Gong T, Lundholm C, Rejno G, et al. Parental asthma and risk of autism spectrum disorder in offspring: a population and family-based case-control study. Clinical and Experimental Allergy. 2019 Feb 11.

 

Summary

This large observational study reports that children of mothers with asthma are at increased risk of developing autism spectrum disorder (ASD). The study looked at all children born in Sweden between 1992 and 2007, including almost 23,000 children with ASD. The researchers posit that maternal immune activation during pregnancy may represent a biological mechanism explaining the association. The increased ASD risk could not be explained by socioeconomic, demographic, or genetic factors, underscoring “the importance of investigating other maternal environmental factors.”

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Published: 2018
SYNOPSIS

The neonatal hepatitis B vaccination induced an anti-inflammatory response lasting for 4–5 weeks.

TITLE

IL-4 mediates the delayed neurobehavioral impairments induced by neonatal hepatitis B vaccination that involves the down-regulation of the IL-4 receptor in the hippocampus

CITATION

Xiao Wang Junhua Yang, Zhiwei Xing, Hongyang Zhang, Yaru Wen, Fangfang Qi, Zejie Zuo, Jie Xu, Zhibin Yao. Cytokine, Volume 110, October 2018, Pages 137-149.

SUMMARY

These experiments showed that IL-4 mediates the delayed neurobehavioral impairments induced by neonatal hepatitis B vaccination, which involves the permeability of neonatal blood–brain barrier and the down-regulation of IL-4 receptor. This finding suggests that clinical events concerning neonatal IL-4 over-exposure, including neonatal hepatitis B vaccination and allergic asthma in human infants, may have adverse implications for brain development and cognition.

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Published: 2008
SYNOPSIS

Children who delayed the timing of the DPT vaccine had lower rates of asthma.

TITLE

Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma?

CITATION

Kara L. McDonald, MS, Shamima I. Huq, BS. Journal of the American Academy of Allergy, Asthma and Immunology, 2008, 121:626-31.

SUMMARY

“Early childhood immunizations have been viewed as promoters of asthma development by stimulating a T(H)2-type immune response or decreasing microbial pressure, which shifts the balance between T(H)1 and T(H)2 immunity. Among 11, 531 children who received at least 4 doses of DPT, the risk of asthma was reduced to (1/2) in children whose first dose of DPT was delayed by more than 2 months.”

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Published: 2000
SYNOPSIS

UCLA researchers find the DTP vaccine is causing asthma.

TITLE

Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in the United States

CITATION

Eric L. Hurwitz, DC, PhD, and Hal Morgenstern, PhD. Journal of Manipulative and Physiological Therapeutics, Volume 23, Number 2, February 2000.

SUMMARY

“Asthma and other allergic hypersensitivity reactions and related symptoms may be caused, in part, by the delayed effects of DTP or tetanus vaccination. Because the proportion of US children who have received at least 1 dose of DTP vaccine approaches 100%, the number of allergies and allergy-related conditions attributable to DTP or tetanus vaccination in the United States may be very high. For example, assuming that the estimated vaccination effect is unbiased, 50% of diagnosed asthma cases (2.93 million) in US children and adolescents would be prevented if the DTP or tetanus vaccination was not administered.”

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