Science Library Category:

Allergies

Published: 2019
SYNOPSIS

About 2–10% of healthy individuals fail to mount antibody levels to routine vaccines.

TITLE

Primary vaccine failure to routine vaccines: Why and what to do?

CITATION

Ursula Wiedermann,* Erika Garner-Spitzer, and Angelika Wagner. Human Vaccines Immunotherapeudics, 2016 Jan; 12(1): 239–243.

SUMMARY

There are 2 major factors responsible for vaccine failures, the first is vaccine-related such as failures in vaccine attenuation, vaccination regimes or administration. The other is host-related, of which host genetics, immune status, age, health or nutritional status can be associated with primary or secondary vaccine failures. The first describes the inability to respond to primary vaccination, the latter is characterized by a loss of protection after initial effectiveness. Our studies concentrate on the evaluation of immunological characteristics responsible for primary vaccine failures in different (risk) populations for which the underlying mechanisms are currently unknown. Here we summarise current knowledge and findings from our studies.

About 2–10% of healthy individuals fail to mount antibody levels to routine vaccines. Comparing the immune responses to different vaccines in non-responder and high-responder vaccinees revealed that hypo-responsiveness is antigen/vaccine-specific at the humoral but not at the cellular level. We found that T-regulatory as well as B-regulatory cells and the production of IL-10 are involved in non/hypo-responsiveness. Non-responsiveness increases with age and in particular vaccination to a novel vaccine in persons > 65 years is associated with a high low/non-responder rate, indicating that vaccine schedules and doses (at least for primary vaccination) should be adapted according to age.

In light of the growing number of allergic but also obese people, our current studies concentrate on these risk groups to reveal whether different vaccination approaches are necessary for optimal protection compared to healthy individuals. These studies are in line with the significant paradigm shift taking place in many fields of medical research and care, and will extend the concept of personalised medicine into the field of vaccinology.

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Published: 2018
SYNOPSIS

An allergic response to thimerosal, nickel, mercury and cobalt often manifests as hand eczema.

TITLE

Hand eczema in children. Clinical and epidemiological study of the population referred to a tertiary hospital

CITATION

Ortiz-Salvador JM, Subiabre-Ferrer D, Rabasco AG, Esteve-Martínez A, Zaragoza-Ninet V, de Miquel VA. Anales de Pediatria (Barc.) 2018; 88:309—314.

SUMMARY

Hand eczema is a common condition in children. The most common cause is atopic dermatitis, although cases of allergic contact dermatitis manifesting as hand eczema are not uncommon. Using children with hand eczema exclusively, researchers conducted patch-testing. The most frequent allergens detected were thimerosal, nickel, mercury and cobalt.

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Published: 2017
SYNOPSIS

Authors review cases of autoimmune reactions following vaccinations to determine underlying cause.

TITLE

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

CITATION

Vadalà M, Poddighe D, Laurino C, Palmieri B. European Association for Predictive Preventive & Personalized Medicine Journal, 2017 Jul 20;8(3):295-311.

SUMMARY

In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals.

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Published: 2017
SYNOPSIS

Vaccinated homeschool children were found to have a higher rate of allergies and neurodevelopmental disease than unvaccinated homeschool children.

TITLE

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children

CITATION

Anthony R Mawson, Brian D Ray, Azad R Bhuiyan and Binu Jacob. Journal of Translational Science, (2017), Volume 3(3): 1-12.

SUMMARY

This study aimed 1) to compare vaccinated and unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders (NDD), if any, remained significant after adjustment for other measured factors and found that while vaccination remained significantly associated with NDD after controlling for other factors, preterm birth coupled with vaccination was associated with an apparent synergistic increase in the odds of NDD.

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Published: 2015
SYNOPSIS

Vaccines implicated in epidemic of food allergies.

TITLE

Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy

CITATION

Vinu Arumugham. (2015) Journal of Developing Drugs 4: 137. doi:10.4172/2329-6631.10001372015.

SUMMARY

“Numerous studies have demonstrated that food proteins contained in vaccines/injections induce food allergy. The IOM’s authoritative report has concluded the same. Allergen quantities in vaccines are unregulated. Today kids are more atopic. C-section births bias the newborn’s immune system towards IgE synthesis due to sub-optimal gut microbiome [19]. C-section birth rates have gone up 50% in the last few decades. The vaccine schedule has increased the number of vaccine shots to 30-40 and up to five vaccines are simultaneously administered to children. Vaccines also contain adjuvants such as aluminum compounds and pertussis toxin that bias towards IgE synthesis. Given these conditions, the predictable and observed outcome is a food allergy epidemic.”

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Published: 2009
SYNOPSIS

Swedish researchers found that children who had natural measles infection had much lower rates of allergy than children vaccinated against measles.

TITLE

Allergic Disease and Atopic Sensitization in Children in Relation to Measles Vaccination and Measles Infection

CITATION

Rosenlund H1, Bergstrom A, Alm JS, Swartz J, Scheynius A, van Hage M, Johansen K, Brunekreef B, von Mutius E, Ege MJ, Riedler J, Braun-Fahrlander C, Waser M, Pershagen G, PARSIFAL Study Group. Pediatrics, 2009.

SUMMARY

“However, in these analyses, measles infection [natural measles] was inversely associated with any allergic symptom or physician’s diagnosis of allergy.”

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Published: 2000
SYNOPSIS

UCLA researchers find the DTP vaccine is causing asthma.

TITLE

Effects of Diphtheria-Tetanus-Pertussis or Tetanus Vaccination on Allergies and Allergy-Related Respiratory Symptoms Among Children and Adolescents in the United States

CITATION

Eric L. Hurwitz, DC, PhD, and Hal Morgenstern, PhD. Journal of Manipulative and Physiological Therapeutics, Volume 23, Number 2, February 2000.

SUMMARY

“Asthma and other allergic hypersensitivity reactions and related symptoms may be caused, in part, by the delayed effects of DTP or tetanus vaccination. Because the proportion of US children who have received at least 1 dose of DTP vaccine approaches 100%, the number of allergies and allergy-related conditions attributable to DTP or tetanus vaccination in the United States may be very high. For example, assuming that the estimated vaccination effect is unbiased, 50% of diagnosed asthma cases (2.93 million) in US children and adolescents would be prevented if the DTP or tetanus vaccination was not administered.”

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