Plasticizers are additives to other substances to increase the flexibility or decrease the viscosity of a material. They are also known as man-made pollutants. Much debate has been going on in recent years concerning plasticizer toxicity to humans, despite research finding phthalate and Bisphenol A (BPA) plasticizers easily enter the human body and metabolize, causing serious biological effects linked to developmental disorders in children, and substantial investigations found these pollutants to be of insult to various organs, including the reproductive system, pulmonary, central nervous system, immune system and liver. Toxic reactions are also reported involving inflammation, mitochondria, and carcinogenicity.