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Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases

immune stimulation with vaccines. Extensive evidence links vaccine induced immune over load with the epidemic of type 1 diabetes. More recent data indicates that obesity, type 2 diabetes and other…

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system

…rapidly solubilized in the extracellular space, injected aluminum particles are quickly captured by immune cells and transported to distant organs and the brain where they elicit an inflammatory response and…

Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

…within-host. Rapidly-replicating viruses that have evolved with bat immune systems will likely cause enhanced virulence following emergence into secondary hosts with immune systems that diverge from those unique to bats….

Subcutaneous injections of aluminum at vaccine adjuvant levels activate innate immune genes in mouse brain that are homologous with biomarkers of autism

…aluminum triggered innate immune system activation and altered neurotransmitter activity in male mice, observations which are consistent with those in autism. Female mice were less susceptible to aluminum as the…

Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders

Citation Beversdorf DQ, Stevens HE, Jones KL. Current Psychiatry Reports. 2018;20:76.   Summary Prenatal stress and disruption of a pregnant woman’s immune response (“maternal immune activation”) are two environmental factors…

Differential durability of immune responses to measles and mumps following MMR vaccination.

These data suggest that specific immune outcomes may wane at different rates and highlight our currently incomplete understanding of protective immune responses to mumps and measles….

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

…A, Ashwood P. Brain, Behavior, and Immunity. 2018;70:354-368. SUMMARY Children with autism spectrum disorder (ASD) and concurrent gastrointestinal (GI) symptoms have a more imbalanced immune response, a more disturbed gut…

T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains

…ASD brain, inflammatory cytokine and transcript profiling shows increased expression of genes encoding mediators of the innate immune response. We evaluated postmortem brain tissue for adaptive immune cells and immune

Interindividual variations in the efficacy and toxicity of vaccines

CITATION Chandan Thomasa, Majid Moridanib. Toxicology 278, 2010 204-210. SUMMARY “A number of currently available vaccines have shown significant differences in the magnitude of immune responses and toxicity in individuals…

Prospects for a safe COVID-19 vaccine

Although animal models of SARS-CoV-2 infection may elucidate mechanisms of immune protection, we need observations of enhanced disease in people receiving candidate COVID-19 vaccines to understand the risk of immune

Milk containing vaccines cause milk allergies, EoE, autism and type 1 diabetes

…and chronic illness, the author criticizes the researchers for overlooking “a major cause of why food has become dangerous,” noting that vaccines contain food proteins that can “program the immune

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum

…specific immune response against antigens and may produce autoimmunity and autoimmune disease in experimental models and humans. “The clinical and laboratory data support an association between adjuvants and autoimmune diseases.”…

Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations

CITATION L Tomljenovic, CA Shaw. Lupus. 2012;21:223–230. SUMMARY “Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence…

Investigating the aetiology of adverse events following HPV vaccination with systems vaccinology.

…might arise from malfunctions within the immune system when confronted with the unusual antigen. In addition, we outline how the pathophysiology of the AEFIs can be cost-effectively investigated with the…

Acute exposure and chronic retention of aluminum in three vaccine schedules and effects of genetic and environmental variation

…results in a high degree of chronic aluminum toxicity in the first seven months of life—a time period critically important to neurodevelopment and immune system development. The authors reached this…

Autoimmune Diseases and Gut Symbionts: The Unpopular Liaison

…GM partake in autoimmune conditions was put forward. Although genetic variability have been proven to contribute towards the pathogenesis of autoimmune conditions, epigenetics control have gained interest among researchers. Current…

Evidence that food proteins in vaccines cause the development of food allergies and its implications for vaccine policy

…in vaccines are unregulated. C-section births bias a newborn’s immune system toward IgE synthesis due to the development of a suboptimal gut microbiome. Vaccines contain adjuvants such as aluminum compounds…

Neurologic adverse events following vaccination

CITATION Sienkiewicz D, Kulak W, Okurowska-Zawada B, Paszko-Patej G. Progress in Health Sciences. 2012;2. SUMMARY “[I]t is not reasonable to assume that manipulation of the immune system through an increasing…

Corrigendum to “Acute exposure and chronic retention of aluminum in three vaccine schedules and effects of genetic and environmental variation”

…flora and that differences in immune responses and clinical disease are due to the influence of microbial differences. There is potential for future research using Gn pigs to test childhood…

Interacting, Nonspecific, Immunological Effects of Bacille Calmette-Guérin and Tetanus-diphtheria-pertussis Inactivated Polio Vaccinations: An Explorative, Randomized Trial

…innate immune responses and lead to protection against mortality from unrelated infections (trained immunity). In contrast, in spite of the disease-specific effects, an enhanced overall mortality has been described after…

Measles Virus Neutralizing Antibody Response, Cell-Mediated Immunity, and Immunoglobulin G Antibody Avidity Before and After Receipt of a Third Dose of Measles, Mumps, and Rubella Vaccine in Young Adults

…see if it would make a difference in waning immunity. Immunogenicity was assessed over 1 year. Most subjects were seropositive before MMR3 receipt, and very few had a secondary immune

Measles outbreak in a fully immunized secondary-school population.

…We conclude that outbreaks of measles can occur in secondary schools, even when more than 99 percent of the students have been vaccinated and more than 95 percent are immune….

Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: a possible role of fluoride and aluminum

Citation Strunecka A, Blaylock RL, Patocka J, Strunecky O. Surgical Neurology International. 2018;9:74.   Summary Children experience sequential immune stimulation from a growing number of neurotoxic metals and chemicals, vaccines…

Mesenchymal stem cells in treating autism: novel insights

…in regenerative medicine, with the potential to address the immune dysregulation often observed in autism spectrum disorder (ASD). This study describes a variety of mechanisms through which MSCs could exert…

Do gut microbiota mediate adverse vaccine reaction?

…differences in immune responses and clinical disease are due to the influence of microbial differences. There is potential for future research using Gn pigs to test childhood vaccines such as…

SARS-like cluster of circulating bat coronavirus pose threat for human emergence

…epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor…

Autoepitopes (22 of 27) in rheumatoid arthritis differ from vaccine antigens by a single amino acid residue, ideal for low affinity self-reactive T cell mediated autoimmunity and a…

…spend the money to completely remove these residual proteins. Due to molecular mimicry between these proteins and human self-proteins, immune responses directed against vaccine proteins can result in autoimmune diseases….

Vaccination with bovine, chick, yeast antigens synthesizes cross-reactive antibodies targeting human acetylcholine receptor and MuSK protein to cause Myasthenia Gravis: Confirmed by natural experiment (VAERS data), bioinformatics, case reports, animal experiments and titer study

Animal protein containing vaccines cause autoimmune diseases even when the vaccine does not contain an adjuvant. Adjuvanted vaccines only make the problem worse. Vaccines interact to cause autoimmune diseases….

Is diphtheria-tetanus-pertussis (DTP) associated with increased female mortality? A meta-analysis testing the hypotheses of sex-differential non-specific effects of DTP vaccine.

…increase in boys [ratio 0.96, 0.55-1.68]). The ways in which the female and the male immune systems may respond differently to vaccinations in infants are only beginning to be studied….

Bioinformatics and epidemiological evidence link yeast protein containing HPV and Hepatitis B vaccines to numerous autoimmune disorders such as vitiligo, narcolepsy, hypothyroidism, systemic lupus erythematosus and rheumatoid arthritis

…arthritis. Zenodo 2018. http://doi.org/10.5281/zenodo.1435404. SUMMARY This bioinformatics analysis confirms that recombinant vaccines containing yeast and immune-boosting adjuvants—the human papillomavirus (HPV) and hepatitis B vaccines—can produce “off-target” autoimmune responses due to…